Human commensal microbiota develop and evolves with us from our birth. The intestinal microbiota is probably the most adaptive component of the human being, allowing for the optimization of its host’s physiology from daily life circumstances to increased life span scales and human evolution. It eventually becomes a vital organ called “core microbiome” optimized for our specific diet, genetic background and life style. Our core microbiome determines our disease resistance physiology and longevity patterns.
Extreme-age people – centenarians – have a microbiota that differs from those of older adults and their key microbiome metabolite profile is also unique. Lifestyle, and diet, play a key role, since aging is often accompanied by a reduction in the amount and variety of fiber-containing foods. Loss of diversity in the core microbiota groups is associated with increased frailty and reduced cognitive performance. The healthy diet diversity index positively correlated with three microbiota diversity indices.
Loss of core microbiome with age with changes in key microbiome metabolite production is a key step which accelerates aging process. We are developing microbiome diversifying and longevity-enhancing secondary metabolite production technologies for several age-groups.